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Zycortal (Desoxycorticosterone)

Written by Dr. Feargus McConnell, BVSc on the Jan.16, 2024

Petdirect is dedicated to providing educational pet health content for pet parents. This article was written and reviewed by veterinary professionals to answer common questions about your pet’s medication. Our focus is on delivering unbiased information to help you understand how medication works, its potential side effects, and FAQs for your reference. Always administer medication directly as prescribed by your vet. This article shouldn’t take the place of advice from your vet.

What is Zycortal Injection?

Zycortal® is an injectable medication used to treat Addison’s disease in dogs (hypoadrenocorticism). Addison’s disease develops when the adrenal glands do not produce enough of the hormone aldosterone and cortisol. Symptoms can include lethargy, decreased appetite, weight loss and increased thirst and urination, trembling and weakness. Zycortal acts as a replacement therapy for hormone deficiency.

How does it work?

Zycortal is long-acting and works by replacing the missing aldosterone. It's like a substitute hormone that helps the body hold onto fluids and maintain the proper balance of electrolytes. This helps to improve the symptoms of Addison's disease and keeps the dog feeling better. It emulates the function of missing hormones to help the body to retain water, supporting normal blood volume and pressure.

Dose and Administration

Dogs should receive an initial dose based on body weight, administered by subcutaneous injection. The dosing intervals and amounts vary based on each dog's response and should be adjusted according to clinical signs and serum sodium/potassium ratios. It's important to shake the vial well before each use.

Overdose:

In case of an emergency or suspected overdose, contact your veterinarian or the New Zealand National Poisons Centre at www.poisons.co.nz/animal-helpline/ or call 0800 869 738 for immediate assistance.

Contraindications and Precautions

Zycortal should not be used in dogs with congestive heart disease, severe renal disease, primary hepatic failure or oedema. This product is also not for use in bitches that are pregnant or lactating.

Potential Side Effects

Zycortal side effects may include drinking and urinating more, and inappropriate urination. Uncommon reactions are lethargy, hair loss, panting, vomiting, decreased appetite, anorexia, decreased activity, depression, diarrhoea, eating more, shaking, tiredness and urinary tract infection.

Monitoring

Your vet will likely recommend regular revisits and diagnostic testing. The dosage might need adjustment based on these results and the dog's clinical response.

Storage

Store Zycortal® Suspension at a controlled room temperature of 25°C. Discard within 120 days of opening.

Frequently Asked Questions (FAQ)

What is Zycortal® Suspension used for in dogs?

  • Zycortal® Suspension is used as a replacement therapy for mineralocorticoid deficiency in dogs with Addison's disease.

How is Zycortal® Suspension administered?

  • It is administered by subcutaneous injection (under the skin).  

What are the main side effects of Zycortal® Suspension?

  • Some dogs may experience side effects such as increased thirst and urination, weight gain.

Can Zycortal® Suspension be used for cats?

  • No, Zycortal® Suspension is specifically formulated for use in dogs.

Conclusion

We hope this article provides a clear understanding of Zycortal for your pet. Remember, always seek advice from your veterinarian for any health-related decisions for your pets.