Xarelto (Rivaroxaban)

Xarelto (Rivaroxaban) is a prescription anticoagulant medication used in humans that may be prescribed off-label by veterinarians for use in some pets under specific circumstances. Xarelto contains the active ingredient Rivaroxaban and can be prescribed for conditions in cats and dogs, including:

• Prevention of blood clots in pets with protein-losing enteropathy or nephropathy.
• Management of immune-mediated haemolytic anaemia to prevent clot formation.
• Treatment of aortic thromboembolism (blood clot in the aorta artery).

This oral medication functions by inhibiting Factor Xa, a critical component in the blood clotting process. Its primary use is to manage and prevent thromboembolic disorders where blood clots form and lodge in blood vessels, obstructing blood flow to parts of the body.

Xarelto is an oral medication in which dose and frequency will depend on your pet's specific condition. Always give as directed by your vet.  

Overdose:

An overdose of Xarelto may lead to internal and/or external bleeding. This can manifest as black or bloody stools, nosebleeds, bleeding gums, pale gums, collapse, lethargy and weakness. If you suspect an overdose contact your veterinarian or the New Zealand National Poisons Centre at www.poisons.co.nz/animal-helpline/ or phone 0800 869 738.

Use cautiously or avoid use in the following situations:

• Known Hypersensitivity: Avoid use in animals known to be hypersensitive to this medication.
• Bleeding Disorders: Contraindicated in animals with increased risk of bleeding due to conditions such as gastrointestinal ulcers, bleeding disorders (e.g., von Willebrand's disease), or recent surgery.
• Liver disease.
• Pregnancy and Lactation: The effects of Xarelto on pregnancy and lactation in animals are not well studied, so its use in pregnant or lactating animals is not recommended.
• Alongside other medications: Use cautiously in conjunction with other medications known to increase bleeding risk, such as NSAIDs, certain steroids, or other anticoagulants.

The most significant risk associated with Xarelto, as with other anticoagulants, is the increased risk of bleeding. This can manifest as black or bloody stools, nosebleeds, bleeding gums, or pale gums, collapse, weakness and lethargy. Animals may experience vomiting, diarrhoea, or signs of abdominal discomfort.

Store at room temperature out of reach of pets and children.

Regular monitoring of blood clotting time by your vet is likely to be recommended.

What is Xarelto used for in cats and dogs?

• Xarelto is used to prevent and treat blood clots in various conditions such as protein-losing diseases, immune-mediated haemolytic anaemia, and certain types of thromboembolism.

How is Xarelto administered?

• Xarelto is an oral tablet. The initial dose is typically twice daily, however your vet will advise you regarding the exact dosage and frequency.

Can Xarelto be used in all pets?

• Xarelto should be avoided in pets with bleeding disorders and its use should always be under the guidance of a veterinarian.

How is the effectiveness of Xarelto monitored?

• The effectiveness is often monitored through Prothrombin Time tests, aiming for specific therapeutic ranges.

What should I do if I suspect an adverse reaction in my pet?

• If you suspect your pet is having an adverse reaction to Xarelto, contact your veterinarian immediately or the New Zealand National Poisons Centre at www.poisons.co.nz/animal-helpline/ or phone 0800 869 738.

We hope this article provides a clear understanding of Xarelto for your pet. Remember, always seek advice from your veterinarian for any health-related decisions for your pets.