Vetoryl (Trilostane)

Vetoryl is used to treat Cushing’s disease, primarily in dogs. Vetoryl® is formulated with Trilostane as its key active component and comes in varying concentrations, including 10mg, 30mg, and 50mg dosages. This is commonly used for treating hyperadrenocorticism, also known as Cushing's Disease, in dogs. This condition occurs when a pet's adrenal glands produce excess amounts of cortisol (a steroid naturally occurring in the body).

The key ingredient Trilostane in Vetoryl® is responsible for decreasing cortisol levels. As a synthetic enzyme, Trilostane functions by inhibiting the enzyme involved in cortisol production. While it doesn't cure Cushing's Disease, it can effectively manage the condition and enhance the quality of life of affected pets.

The administration of Vetoryl® should be as directed by your veterinarian. Typically, it's given once daily with food to enhance its absorption. Generally, it is recommended to start with the lowest possible dose, and through regular testing/monitoring this can be adjusted by your veterinarian after 10-14 days.

Missed Dose:

If you miss a dose, administer it as soon as you remember. However, if it's nearly time for the next dose, skip the missed one and continue with the regular schedule. Avoid giving double doses. Consult your veterinarian if you have any concerns regarding this.

Overdose:

An overdose of Vetoryl® may lead to severe adrenal gland suppression. Symptoms can include loss of appetite, lethargy, weight loss, diarrhoea, muscle tremors, and collapse. If you suspect an overdose, seek veterinary assistance immediately or call New Zealand National Poisons Centre (www.poisons.co.nz/animal-helpline/ or 0800 869 738).

It is important to consult with your veterinarian if Vetoryl® is the correct choice for your pet. However, it is generally not recommended for dogs with primary hepatic or renal disease, or in pregnant dogs.  

The most common side effects reported with Vetoryl® were:

• Vomiting
• Lethargy
• Appetite loss
• Weakness
• Diarrhoea (possibly bloody)
• Collapse

Contact your veterinarian immediately if these symptoms occur.

Vetoryl® should be stored at a controlled room temperature avoiding extreme heat. It is important to ensure the container is tightly closed to protect from moisture and light. Keep this medication out of reach of children and pets.

Trilostane may decrease testosterone synthesis, has anti-progesterone properties, and may cause abortions. Women who are pregnant or are intending to become pregnant should avoid handling the capsules. Wash hands with soap and water following accidental exposure and after use. The content of the capsules may cause skin and eye irritation and sensitisation. Do not divide or open capsules: in the event of accidental breakage of the capsules and contact of the granules with eyes or skin, wash immediately with plenty of water. If irritation persists, seek medical advice. In the event of accidental ingestion, seek medical advice immediately and show the package leaflet or carton to the physician.

After starting your pet on Vetoryl treatment, regular monitoring is often advised to ensure their well-being. Many veterinarians suggest scheduling tests to measure your pet's biochemistry (which covers electrolyte levels) and conducting ACTH stimulation tests.

These tests are generally recommended:

• 10 to 14 days after initiating Vetoryl treatment,
• Then again 30 days after starting,
• Followed by a check-up 90 days later,
• Continuing with tests every 3 months from that point onwards.

This routine helps in assessing how effectively the treatment is working and maintaining your pet’s health.

How long does it take for Vetoryl® to work?

• Since each pet is unique, it's important to consult with your veterinarian. Typically, Vetoryl® starts to take effect within 1-2 days, although it might take several weeks before noticeable changes are observed.

Can I stop giving Vetoryl® if my pet seems better?

• Do not stop administering this medication without consulting your veterinarian. Always consult with your vet before making any changes to your pet's medication regimen.

What could I expect in the first 1-2 weeks of using Vetoryl® ?

• When discussing Vetoryl® treatment with your vet, remember each dog is unique and requires individual consideration. Commonly, owners report their dogs show improvements such as less frequent drinking and urination, reduced excessive hunger, and decreased panting. A notable increase in energy, particularly evident at the initial 10-14 day check-up, is also often observed.

How long does it typically take for symptoms to improve after starting treatment with Vetoryl®?

• While every pet responds differently to treatment, some have shown significant improvement within 6 months of starting Vetoryl® for hyperadrenocorticism. In a 6-month clinical trial conducted by Dechra involving 60 dogs, it was observed that up to 85% of them no longer exhibited the clinical signs typically associated with hyperadrenocorticism after this period.