Vedafil (Sildenafil)

Vedafil is a human medication that a veterinarian may prescribe off-label to treat high blood pressure (hypertension) in dogs and cats. It contains the active ingredient Sildenafil which is commonly used in dogs and cats to address pulmonary arterial hypertension, which is high blood pressure in the blood vessels of the lungs. In dogs, it may also be used to help manage megaesophagus.

In treating pulmonary arterial hypertension, the active component Sildenafil operates by relaxing and widening the lung's blood vessels. This action reduces the effort required for the heart to pump blood through these vessels. For dogs with megaesophagus, Sildenafil helps by relaxing the muscle at the end of the oesophagus, aiding in food passage to the stomach.

Always read the medication label and give it as directed by your veterinarian. Vedafil is typically given two or three times daily depending on the nature of the health issue being treated. It is typically given without food, but in cases where a pet experiences digestive issues, a small amount of food might be recommended by the veterinarian.

Missed Dose:

If a dose is missed, it is typically recommended to give the dose as soon as you remember. If it's almost time for the next dose, skip the missed dose and give the next dose at the scheduled time.

Overdose:

Signs of overdose include low blood pressure, weakness, vomiting, high heart rate, and lethargy. In such cases, immediate veterinary care is crucial or contact the New Zealand National Poisons Centre at www.poisons.co.nz/animal-helpline/ or phone 0800 869 738

Known hypersensitivity: Pets with allergies to sildenafil or any ingredients should avoid it to prevent potentially severe allergic reactions.

Nitrate drugs: Combining sildenafil with nitrates is dangerous due to the risk of a significant drop in blood pressure.

Severe liver impairment: Reduced liver function can alter sildenafil metabolism, increasing the risk of side effects.

Severe renal impairment: Impaired kidney function can affect sildenafil elimination, potentially leading to toxicity.

Certain medication interactions: Specific medications can interact with sildenafil, causing complications. Consulting a veterinarian is crucial before administering sildenafil alongside other medications.

Severe cardiovascular disease: While sildenafil is used for specific heart conditions in pets, its use might be contraindicated in cases of severe cardiovascular disease due to potential risks exceeding potential benefits.

While Vedafil is generally well-tolerated, some pets may experience side effects, including:

• Vomiting
• Diarrhoea
• Decreased appetite
• A flush red appearance to the skin

If any of the symptoms above are observed, contact your veterinarian immediately.

Store at a controlled room temperature and keep away from moisture, light, and out of reach of children and pets.

What is Vedafil (sildenafil) used for in dogs and cats?

• Sildenafil is primarily used to treat pulmonary arterial hypertension (PAH) in dogs and cats. It works by dilating blood vessels in the lungs, which lowers blood pressure in these vessels and improves the animal's ability to exercise and overall quality of life.

How is Vedafil (sildenafil) administered to pets, and what is the typical dosage?

• Sildenafil is administered orally in the form of tablets. The dosage varies based on the pet's weight, the severity of the condition, and the individual response to the medication. A veterinarian will determine the appropriate dosage and frequency.

Are there any side effects of Vedafil (sildenafil) in pets?

• Yes, potential side effects may include gastrointestinal disturbances (such as vomiting and diarrhea), hypotension (low blood pressure), and an increased heart rate. It's important to monitor your pet for any adverse reactions and consult your veterinarian if you have concerns.

Can all pets take Vedafil (sildenafil)?

• Not all pets are suitable candidates for sildenafil. Always consult with a veterinarian before starting sildenafil to ensure it's safe for your pet.