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Trental (Pentoxifylline)

Written by Dr. Feargus McConnell, BVSc on the Jan.16, 2024

Petdirect is dedicated to providing educational pet health content for pet parents. This article was written and reviewed by veterinary professionals to answer common questions about your pet’s medication. Our focus is on delivering unbiased information to help you understand how medication works, its potential side effects, and FAQs for your reference. Always administer medication directly as prescribed by your vet. This article shouldn’t take the place of advice from your vet.

What is Trental?

Trental is a medication used to improve blood circulation. It is a human medication that may be prescribed off-label by a veterinarian for dogs and cats. The active ingredient is Pentoxifylline. In pets, it may be used to treat various skin conditions and inflammation of small blood vessels that lead to poor blood flow.

How does it work?

Pentoxifylline helps blood flow smoothly through small blood vessels in the body and reduces inflammation. It increases the flexibility of red blood cells, reduces blood thickness, and helps break down blood clots. This allows the red blood cells to better delivery deliver oxygen to tissues and improves circulation. It decreases inflammation by reducing the amount of inflammatory biochemicals in parts of the body. It may be used in the treatment of conditions such as cutaneous vasculitis, canine familial dermatomyositis, allergic dermatitis, and atopic dermatitis.

Dose and Administration

Trental should be administered as directed by a veterinarian. Typically, it is given with food, and the frequency of administration depends on the pet's specific condition. Always follow the guidelines provided by your vet.

Missed Dose:

If you miss a dose, consult your vet. They might advise giving it when remembered, or if it's close to the next dose, to skip the missed one and continue as normal. Avoid giving extra or double doses.

Overdose:

Symptoms of an overdose in pets can include vomiting, loss of appetite, increased heart rate, bloody diarrhoea, bleeding, drooling, and seizures. In case of a suspected overdose, seek immediate veterinary attention or the New Zealand National Poisons Centre at www.poisons.co.nz/animal-helpline/ or phone 0800 869 738.

Contraindications and Precautions

Pentoxyfylline should not be given to animals allergic to xanthines. It is not recommended for pets with bleeding disorders, history of stroke or retinal hemorrhage, severe liver or kidney disease, and pregnant or nursing animals. It is important to use this medication only under veterinary guidance.

Potential Side Effects

Side effects in dogs and cats are rare but may include vomiting, diarrhoea, loss of appetite, and agitation. If side effects are observed or the pet's condition worsens, contact your veterinarian.

Storage

Store Trental at controlled room temperatures, ensuring the container is tightly sealed to protect from moisture and light. Always keep medications out of reach of children and pets.

Frequently Asked Questions (FAQ)

What is Trental used for in dogs and cats?

  • Trental (Pentoxifylline) is used to improve blood circulation in dogs and cats, often prescribed for conditions such as skin ulcers, vasculitis, or certain circulatory disorders, enhancing blood flow to areas with poor circulation.

How is Trental administered to pets?

  • Trental is typically administered orally, in the form of tablets. The dosage and frequency depend on the pet's specific condition, weight, and veterinary recommendations.

What are the potential side effects of Trental in pets?

  • Side effects can include vomiting, diarrhoea, lack of appetite, and lethargy. More serious side effects are rare but can occur, so close monitoring by a veterinarian is important.

Can all pets take Trental?

  • Not all pets are good candidates for Trental. It should not be used in animals with recent bleeding, or severe kidney or liver disease without consulting a veterinarian. A thorough evaluation by a vet is necessary to determine if Trental is a safe option for your pet.

Conclusion

We hope this article provides a clear understanding of Trental for your pet. Remember, always seek advice from your veterinarian for any health-related decisions for your pets.