Written by Dr. Feargus McConnell, BVSc on the Jan.16, 2024
Petdirect is dedicated to providing educational pet health content for pet parents. This article was written and reviewed by veterinary professionals to answer common questions about your pet’s medication. Our focus is on delivering unbiased information to help you understand how medication works, its potential side effects, and FAQs for your reference. Always administer medication directly as prescribed by your vet. This article shouldn’t take the place of advice from your vet.
Sertraline, commonly known under the brand name Setrona, is a medication that may be prescribed for pet behavioural problems. Setrona is a human antidepressant medication that may be prescribed off-label by a veterinarian for pets under their care. It may be prescribed as part of a treatment plan to address behaviours linked to fear, anxiety, stress, and obsessive-compulsive disorders in dogs and cats. Antidepressants are not typically the first option for pets and are usually considered after behaviour modification and other therapies have been attempted. Setrona should be used in conjunction with behaviour modification techniques.
As an SSRI (selective serotonin reuptake inhibitor), Sertraline operates by blocking the reabsorption of serotonin, a neurotransmitter, into the nervous system. This action allows more serotonin to remain available in the space between nerve cells. This increased availability allows for better communication between nerve cells, which may contribute to improved mood regulation and behaviour.
Follow your veterinarian's instructions and give as directed. As this is a tablet medication, it can be helpful to disguise it in flavoured food to encourage positive reinforcement. It can be taken with or without food. If vomiting occurs on an empty stomach, take with food.
Missed Dose:
If you miss a dose, give it when you remember. If it's almost time for the next dose, skip it and give the dose at the next scheduled time. Don't double dose.
Overdose:
If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately or call the New Zealand National Poisons Centre at 0800 869 738. Visit www.poisons.co.nz/animal-helpline/ for more information.
Known hypersensitivity: Do not use in pets with a known allergy to sertraline or any component of its formulation.
Concurrent use with MAOIs: Avoid using in pets currently on or recently weaned off monoamine oxidase inhibitors (MAOIs) due to the risk of serotonin syndrome.
Use with caution in pets with liver disease: Sertraline is metabolized by the liver, so pets with liver disease may require adjusted dosing or alternative treatments.
Pregnancy and nursing: The safety of sertraline in pregnant or nursing pets is not well established.
Seizure disorders: Use with caution in pets with a history of seizures, as SSRIs can lower the seizure threshold.
Some pets may experience side effects that could include:
Decreased appetite, vomiting, diarrhoea, lethargy, irritability, sleeplessness, panting (in dogs). Taking too much sertraline can lead to symptoms such as drowsiness, sedation, unsteadiness, hyperactivity, alterations in heart rhythm and blood pressure, shaking, and a rise in body temperature. In case of an overdose, it's crucial to immediately contact your vet or emergency veterinary clinic.
Store Sertraline at a controlled room temperature, away from moisture and light. Ensure the container is tightly closed and kept out of reach of children and pets.
How long does it take for Setrona to work?
Is there a difference between human and animal Setrona?
Can I use human-prescribed Sertraline for my pet?
While Setrona can be a helpful medication for managing certain behavioural issues in dogs and cats, it's essential to use it under the guidance of a veterinarian. We hope this article provides a clear understanding of Setrona for your pet. Remember, always seek advice from your veterinarian for any health-related decisions for your pets.