Prednisone (Prednisone)

Prednisone is a synthetic corticosteroid similar to natural glucocorticoids produced by the body. It is often prescribed by veterinarians to treat various inflammatory and immune-mediated conditions in dogs and cats. These conditions may include itchy skin, hives, allergic reactions, inflammatory skin disorders, Addison's Disease, Inflammatory Bowel Disease (IBD), arthritis, autoimmune disorders, neurological conditions, asthma, and certain types of cancer. Additionally, it's important to note that prednisone is a powerful medication with potential side effects, so it's crucial to consult a veterinarian for diagnosis and a proper treatment plan using this medication.

Prednisone works by binding to glucocorticoid receptors in various cell types throughout the body. This interaction influences multiple processes, including reducing inflammation and suppressing the immune system. Lower doses typically have a more prominent anti-inflammatory effect, while higher doses can have a stronger immunosuppressive effect. However, both effects occur to some degree at any dose, and the specific balance depends on various factors.

It's crucial to follow the dosage instructions provided by your veterinarian and the medication label. The dosage may change over the treatment course. Long-term treatment with these medications might interfere with the body's natural steroid production. Therefore, veterinarians typically recommend a gradual dose reduction over time.

Missed Dose:

If you miss a dose, administer it as soon as you remember. However, skip the missed dose if it's almost time for the next one. Do not double the dose.

Overdose:

In case of an overdose, contact your veterinarian or the New Zealand National Poisons Centre (www.poisons.co.nz/animal-helpline/ or 0800 869 738) immediately.

Prednisone should not be given to pets with known allergies to corticosteroids. It should not be given to pets currently being treated with non-steroidal anti inflammatories drugs (NSAIDs). It can worsen fungal infections, suppress the immune system, increase the risk of ulcers, worsen Cushing's disease, worsen osteoporosis, and interfere with growth and development in young animals. It should be used cautiously in pets with pre-existing heart problems, and only in pregnant or lactating animals when the potential benefits outweigh the risks.

Prednisone is a powerful medication that can have various side effects depending on the dosage and duration of use. Common side effects include increased thirst, urination, appetite, panting, and vomiting or diarrhea. Long-term or high-dose use may increase the risk of additional side effects like weight gain, poor hair coat, muscle wasting, decreased energy, digestive ulcers, diabetes mellitus, and behavioral changes. It's important to note that prednisone can also potentially increase susceptibility to certain infections, but the specific risks depend on various factors.

Store Prednisone at controlled room temperatures, avoiding extreme heat. Always confirm storage requirements on the label or with your veterinarian. For safety keep out of reach of children and other pets.

Is Prednisone a diuretic for dogs?

• No, Prednisone is not a diuretic. However, it can affect water and electrolyte balance, leading to increased thirst and urination.

Is Prednisone a painkiller for dogs?

• Prednisone is not a painkiller, but its anti-inflammatory properties can relieve pain caused by inflammation.

How long does it take for Prednisone to work in dogs?

• Prednisone starts working within 1-2 hours of administration, with symptom improvement following shortly after.

What is the difference between Prednisone vs Prednisolone?

• Prednisone is a prodrug, which means it needs to be converted by the liver into its active form, Prednisolone, to be effective. This conversion process is efficient in dogs, however, cats have a less efficient ability to convert Prednisone into Prednisolone. Therefore, Prednisolone is often the preferred choice for cats ensuring more consistent and effective treatment.