Pexion (Imepitoin)

Pexion contains Imepitoin as the active ingredient. Pexion (Imepitoin) acts on the dog’s central nervous system and is an anti-epileptic drug which is prescribed for reducing the frequency of generalised seizures due to idiopathic epilepsy in dogs. It is available in two concentrations; 100 mg and 400 mg. Pexion is commonly prescribed after considering other treatment options.

Pexion is an anti-epileptic and anti-anxiety medicine. Epilepsy is caused by excessive electrical activity in the brain. Pexion works by activating brain receptors and chemicals that reduce electrical activity in the brain. Brain chemicals such as GABA allow nerve cells to communicate with each other. By activating GABA receptors, Pexion increases GABA’s effects and helps to prevent seizures.

Pexion is indicated for dogs diagnosed with idiopathic epilepsy. The exact dosage depends on the dog's weight and the severity of the condition which will be evaluated by your veterinarian. It is typically administered orally twice daily, approximately 12 hours apart. Tablets can be administered with or without food, although studies suggest the medication is better absorbed in dogs that have been fasted. The timing of tablet administration in relation to feeding should be kept consistent. Always follow your vet's advice and give as directed on the medication label.

Overdose:

In cases of overdose, symptoms such as central nervous system effects or gastrointestinal issues. With treatment the dog should make a full recovery and these are generally not life-threatening and. For emergencies of suspected overdose, contact your veterinarian or the New Zealand National Poisons Centre (www.poisons.co.nz/animal-helpline/ or phone 0800 869 738).

Pexion is typically contraindicated in dogs with severely impaired liver, kidney, or cardiovascular functions. Caution is advised for dogs weighing less than 5 kg, with pre-existing health conditions or during pregnancy/lactation. Abrupt termination of treatment may lead to adverse effects on the dog’s behaviour and muscles. It is important to consult your veterinarian before stopping treatment.

While Pexion is generally well-tolerated and safe, some dogs may experience the following side effects:

• Increased appetite
• Hyperactivity
• Increased drinking and urination
• Drowsiness, sleepiness
• Hypersalivation
• Vomiting
• Ataxia (difficulty walking)
• Disorientation
• Diarrhoea
• Prolapsed nictitating membrane
• Decreased sight, and sound sensitivity

If the following side effects present, contact your veterinarian immediately.

Securely store Pexion at room temperature, in a dry place. Keep out of sight and reach of children and other pets.

Can Pexion be used for cats?

• Pexion is specifically formulated for use in dogs. Consult your veterinarian to discuss potential options for your cat.

How long does it take for Pexion to work?

• The response time can vary between dogs. Some dogs will be free of seizures. In other dogs a reduction of the number of seizures will be observed. Some dogs may not respond to treatment. In non-responders, an increase in seizure frequency may be observed. Should seizures not be adequately controlled, further diagnostic measures and other antiepileptic treatment should be considered. If seizures are not adequately reduced after one week of treatment, consult your vet for reassessment.

Is Pexion a lifelong treatment?

• The duration of treatment depends on the dog's response and the vet's recommendation. Some dogs may require long-term management.

Can Pexion be used alongside other medications?

• Pexion has been used in combination with phenobarbital without harmful interactions. However, always consult your vet before combining medications.

What should I do if I miss a dose?

• If you miss a dose, administer it as soon as possible. However, if it's almost time for the next dose, skip the missed dose and resume the regular schedule.

Can I stop giving Pexion to my dog if the seizures stop?

• Do not stop the medication without consulting your vet. Abruptly stopping treatment can lead to withdrawal symptoms.