Ovestin (Estriol)

Ovestin (Estriol) is a human medication that may be prescribed by a veterinarian to treat urinary incontinence in spayed female dogs caused by low levels of estrogen. For best results, it should be administered in combination with behavioral modification techniques and a healthy diet. It is a human medication that may be prescribed ‘off-label’ by veterinarians.

Ovestin is a medication that contains estriol as its active ingredient. Estriol is a type of natural and short-acting estrogen that works by improving the muscle tone of the urethral sphincter. This improvement in muscle tone helps to prevent urine leakage. Unlike longer-acting estrogens, estriol's short action duration is associated with a lower risk of serious side effects.

It is important to note that Ovestin dosage for dogs is determined based on individual responses and not by weight. Therefore, it is recommended that a veterinarian be consulted in order to determine the appropriate dosage for your furry friend. In order to gauge treatment success, it is important to monitor your dog's incontinence signs over the course of a week. Although improvements may appear within a few days, it is recommended to follow these general guidelines, or as directed by a vet:

• Begin with an initial loading dose for 14 days.
• Gradually reduce the dosage to determine the minimal effective amount, while closely monitoring your dog's reaction.
• Adjust doses at intervals of at least one week.
• Once the effective dose is found, it may be further reduced to alternate day administration.

Missed Dose:

If a dose is missed please advise with your veterinarian. However, it is usually suggested to be administered as soon as remembered, or skipped if it's nearly time for the next dose.

Ovrdose:

In case of overdose or side effects, immediately contact your veterinarian or the New Zealand National Poisons Centre at www.poisons.co.nz/animal-helpline/  or call 0800 869 738.

Ovestin should be avoided in pregnant dogs, dogs with a history of estrogen-sensitive tumors, unspayed females, and dogs with liver dysfunction or blood clotting disorders. It may worsen symptoms in dogs with pre-existing endocrine disorders.

While Ovestin is generally well-tolerated, some side effects may occur, including:

• Loss of appetite
• Vomiting
• Increased thirst (Polydipsia)
• Swollen vulva
• Swollen teats
• Attractiveness to males
• Alopecia

It's important to monitor your pet for these side effects and consult your veterinarian if they occur.

Ovestin should be stored as advised via the storage label instructions. This usually involves storing at room temperature avoiding any extreme temperatures. Tablets should be kept in their blister packs to protect them from moisture and light. Keep out of reach of children and pets.

Wash hands thoroughly after handling Ovestin. Estriol presents a reproductive risk to humans, and pregnant or breastfeeding women should take extra care if handling.

How Quickly Does Ovestin Work?

• While Ovestin can potentially show results within 1-2 days, each dog is different and some take longer to respond, so the initial course should be 14 days or longer. It's important to consult with your veterinarian for a thorough evaluation of its effectiveness. A comprehensive assessment after two weeks of administration is highly recommended.  

What is the duration of treatment for Ovestin?

• Treatment duration depends on the pet's response to the medication. The dose should be titrated down to the lowest effective dose that resolves incontinence. Regular veterinary check-ups are recommended to monitor the pet's condition and any side effects.

Is Ovestin Safe for Dogs?

• Oestrogen is a naturally occurring hormone in female dogs. Ovestin, containing a low dose of estriol, is generally considered safe for treating urinary incontinence in dogs. However, if you suspect overdose or severe side effects, immediately contact your veterinarian or the New Zealand poisons Centre at www.poisons.co.nz/animal-helpline/ or call 0800 869 738.