Written by Dr. Feargus McConnell, BVSc on the Jan.16, 2024
Petdirect is dedicated to providing educational pet health content for pet parents. This article was written and reviewed by veterinary professionals to answer common questions about your pet’s medication. Our focus is on delivering unbiased information to help you understand how medication works, its potential side effects, and FAQs for your reference. Always administer medication directly as prescribed by your vet. This article shouldn’t take the place of advice from your vet.
Leukeran contains Chlorambucil as the main active ingredient. This is a prescription medication which functions as an oral chemotherapy or anti-cancer (anti-neoplastic) drug. In veterinary medicine, it's primarily used for treating leukaemia in dogs and cats, as well as lymphoma in these pets. Besides its role in cancer treatment, Chlorambucil serves as an immunosuppressant in cases like inflammatory bowel disease and immune-mediated hemolytic anaemia in cats and dogs.
This drug functions as an alkylating agent, binding to the DNA of cancerous cells and hindering their ability to replicate. This eventually leads to the death of these cells. In cases of immune-mediated diseases, Chlorambucil targets an overactive immune system, preventing it from attacking the body's own tissues and organs.
Always wear disposable gloves when handling chlorambucil tablets to prevent skin absorption of the drug. After handling the medication or treating your pet, wash your hands thoroughly with soap and water to remove any residues. Pregnant or nursing women should not handle chemotherapy drugs like chlorambucil due to the risk of absorption and potential harm to the fetus or nursing infant.
The drug should be administered as directed by your veterinarian. It is crucial not to crush or split the tablet, and it's usually recommended to give it with food. The dosage and frequency depend on your pet's specific condition, and your vet will provide precise instructions. Typically, Chlorambucil is given once every 24-72 hours, though this can vary.
Missed Dose:
If you miss a dose, contact your vet for advice. Avoid doubling up on doses.
Overdose:
In case of suspected overdose, immediately seek veterinary care or contact the New Zealand National Poisons Centre at www.poisons.co.nz/animal-helpline/ or 0800 869 738
Leukeran is not suitable for pets with bone marrow disease or those currently battling an infection. It's also advised against using this medication in pregnant or lactating animals. Additionally, exercise caution when administering Leukeran to pets prone to infections, including older pets or those with chronic illnesses. It's important to refrain from vaccinating your pet during the treatment with Leukeran, unless specifically recommended by your veterinarian.
The most common side effect is bone marrow suppression, which can lead to low blood cell counts. Other potential side effects include:
Contact your vet if severe side effects are observed or if your pet's condition worsens.
Chlorambucil should be stored in a sealed plastic container at refrigerated temperatures between 2°C to 8°C. Always check the label for storage requirements and keep the medication out of reach of children and pets.
Always wear disposable gloves when handling chlorambucil tablets to prevent skin absorption of the drug. After handling the medication or treating your pet, wash your hands thoroughly with soap and water to remove any residues. Pregnant or nursing women should not handle chemotherapy drugs like chlorambucil due to the risk of absorption and potential harm to the fetus or nursing infant.
Disposal of Waste: Dispose of any used gloves, empty medication containers, or any material used to handle or clean up chlorambucil in a sealed plastic bag to prevent exposure to others.
Accidental Exposure: In case of accidental skin exposure, wash the area immediately with soap and water. If chlorambucil comes into contact with your eyes, rinse them with water or saline solution for at least 15 minutes and seek medical attention.
How long can a cat and dog stay on Leukeran?
How quickly does Leukeran take effect in pets?
Is Leukeran safe for all breeds of cats and dogs?
Can Leukeran be used with other medications?
Leukeran is a common medication prescribed for chemotherapy in cats and dogs. However, it's crucial to follow your veterinarian's advice regarding its use. We hope this article provides a clear understanding of Leukeran for your pet. Remember, always seek advice from your veterinarian for any health-related decisions for your pets.