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Felimazole (Methimazole)

Written by Dr. Feargus McConnell, BVSc on the Jan.16, 2024

Petdirect is dedicated to providing educational pet health content for pet parents. This article was written and reviewed by veterinary professionals to answer common questions about your pet’s medication. Our focus is on delivering unbiased information to help you understand how medication works, its potential side effects, and FAQs for your reference. Always administer medication directly as prescribed by your vet. This article shouldn’t take the place of advice from your vet.

What is Felimazole?

Felimazole contains Methimazole as the active ingredient which is commonly used to treat hyperthyroidism in cats. Hyperthyroidism in cats is usually the result of a benign change in one or both of the thyroid glands. This results in an overproduction of thyroid hormone and affects the cat’s metabolism. Felimazole can be used to stabilise hyperthyroid cats prior to surgery to remove the thyroid. Common signs of hyperthyroidism can include weight loss despite increased appetite, increased vocalisation, increased drinking and urination, vomiting. The coat of affected cats may appear unkempt or greasy. Cats with hyperthyroidism can appear hyperactive, irritable and at times aggressive.

How does it work?

The active ingredient, Methimazole works by inhibiting the use of iodine by the thyroid gland, essentially decreasing the thyroid gland’s ability to produce thyroid hormones. It's important to note that methimazole is not a cure but helps manage the symptoms by controlling hormone production.

Dose and Administration

Always follow the advice provided by your veterinarian. Felimazole tablets should typically be started at a low dose and then adjusted after three weeks based on the cat's individual response. Preferably, the daily dose will be split in half and given morning and evening. However, if the cat is difficult to give tablets to, then the tablet can be given once daily. Cats should always have access to water while being treated with this medication.

Missed dose:

In case you miss a dose, administer it as soon as you remember. However, if it's almost time for the next dose, it is advised to wait until the next dose is due. Do not give two doses at the same time.

Overdose:

In case of accidental ingestion or overdose, contact your veterinarian or the New Zealand National Poisons Centre at www.poisons.co.nz/animal-helpline/ or 0800 869 738.

Contraindications and Precautions

Methimazole should be used cautiously in pets with liver disease, autoimmune diseases, kidney disease, or blood abnormalities. Treatment may reveal pre existing underlying kidney disease. It is vital to contact your veterinarian immediately if you notice these side effects.

Potential Side Effects

Side effects most common within the first three months may include a lack of appetite, vomiting, diarrhoea, and depression, lethargy.

Storage and Handling

Felimazole should be stored at controlled room temperatures below 25°C, avoiding extreme heat. Ensure the container is tightly sealed to protect from moisture and light. Keep out of reach of children and pets.

Pregnant women should wear gloves when handling this medication. Wash hands thoroughly after handling this medication. As thiamazole is a suspected teratogen, women of childbearing age should wear gloves when handling cat litter used by treated cats.

Monitoring

Prior and during treatment, it's recommended to monitor the cat's health through appropriate blood tests. Regular monitoring every few months is crucial, and for cats on higher doses, more frequent checks may be necessary. Adjustments to the medication should be made as advised by your vet based on these health checks. Note that it is necessary that your cat revisits your veterinary surgeon for assessment and monitoring tests. These are recommended at 3,6,10 and 20 weeks after starting treatment and thereafter every 3 months.

Frequently Asked Questions (FAQ)

How long does Felimazole take to work on cats?

  • Typically it can take 1-3 weeks before significant improvement of clinical symptoms are seen in cats. Consult with your veterinarian what specific changes to anticipate for your cat.

How long will my cat be on Felimazole?

  • The duration is typically a long-term commitment as this medication manages the symptoms rather than curing the underlying condition. However, Felimazole can be used prior to surgery to remove the problematic thyroid. The specific length of treatment can vary depending on the cat's response to the medication. It is essential to work closely with your veterinarian to regularly assess your cat's condition and adjust the treatment plan as needed. Other treatment options for hyperthyroidism include surgery, diet, and radioactive iodine.

Can Felimazole interact with other medications?

  • It is important to inform your veterinarian about all the medications your pet is on before starting Methimazole Spot-on treatment. This ensures the safe management of any potential interactions between Methimazole and other drugs your cat is receiving.

Can Felimazole be used for cats and dogs?

  • Felimazole is a prescription medication for cats. For options for your dog, contact your veterinarian.

Conclusion

Felimazole is a common medication for managing Hyperthyroidism in cats. Consistent application and veterinary monitoring are crucial for its effectiveness. We hope this article provides a clear understanding of Felimazole for your pet. Remember, always seek advice from your veterinarian for any health-related decisions for your pets.