Everet (Levetiracetam)

Everet is a medication that can be used to treat seizures in dogs and cats. It is a human medication that may be prescribed off-label by a veterinarian for use in pets. It is an anticonvulsant medication containing the active ingredient Levetiracetam used to manage and treat seizures and epilepsy. In dogs, it is often used alongside other medication.

The active ingredient in Everet, Levetiracetam, works by affecting several mechanisms in the brain. It primarily modulates neurotransmitters which helps stabilise brain activity and prevent the rapid firing of nerves associated with seizures. Additionally, it may bind to proteins and affect calcium channels, further influencing neurotransmitter release and stabilising nerve cells. This combination of actions helps reduce the frequency and intensity of seizures in pets, although it does not cure the underlying cause.

Give as directed by your veterinarian. The dosage and frequency will be determined by your veterinarian. The dose may require adjusting overtime and other medications may need to be added to the treatment plan to help management of epilepsy. Typically, Everet can be given with or without food, however, if your pet vomits after dosing give future doses with food. Do not crush the tablets. With long-term use tolerance can develop to levetiracetam. If levetiracetam is to be discontinued, taper-off the dose. Do not abruptly stop giving the medication.

Missed Dose:

If you miss a dose, it is typically advised to administer it as soon as you remember and time the next dose accordingly, then resume the regular dosing schedule. However, if it's basically time for the next dose, skip the missed one, and give the next dose at the scheduled time. Do not double-dose or give extra doses.

Overdose:

In case of suspected overdose or adverse reaction, contact your veterinarian immediately or get in touch with the New Zealand National Poisons Centre at www.poisons.co.nz/animal-helpline/ or 0800 869 738.

Known Hypersensitivity: Animals with a known hypersensitivity or allergy to levetiracetam should not be given the medication.

Renal Impairment: Since levetiracetam is primarily excreted through the kidneys, caution is advised in animals with impaired renal function. Dosage adjustments may be necessary.

Pregnancy and Lactation: The safety of levetiracetam in pregnant or lactating animals has not been fully established. Use in these cases should be evaluated by a veterinarian to weigh the potential benefits against risks.

Use with Other Medications: It is important to discuss all medications and supplements your pet is taking with your veterinarian to avoid potential adverse interactions.

Paediatric Use: The safety and effectiveness in very young animals has not been established. Use in paediatric patients should be under the close supervision of a veterinarian.

Abrupt Discontinuation: Avoid suddenly stopping the medication, as this may lead to withdrawal seizures. Any changes in the medication regimen should be made under veterinary supervision.

Everet is generally well tolerated by pets and considered safe, however all medication can cause side effects. All seizure control medications can cause drowsiness. Common side effects in dogs include drowsiness and incoordination, while in cats, decreased appetite, incoordination, drooling, and sleepiness are more common. Serious side effects may include persistent vomiting or sudden behavioural changes. If any of the following side effects are observed, contact your veterinarian immediately.

Store tablets at room temperature below 25 degrees in a dry place. Keep out of reach of children and other pets.

Regular monitoring by a veterinarian is recommended to assess the effectiveness of the medication and to adjust the dosage as needed. It is recommended for owners to keep a diary of seizures and medication doses, especially if changes to medication type and dose are being made. Vets may recommend regular blood testing for epileptic pets.

How quickly does Everet (Levetiracetam) work in pets?

• This can vary between pets, however, it typically takes 1 to 2 hours for the medication to take effect.

Can I stop giving my pet Everet (Levetiracetam) if I notice side effects?

• If you notice side effects it is vital to consult your veterinarian before making any changes to your pet’s medication regimen.

Is regular monitoring necessary while my pet is on Levetiracetam?

• Yes, both at-home seizure monitoring and regular veterinary check-ups are recommended. Recording these in a diary or on your phone is recommended.

What should I do if I miss giving a dose to my pet?

• It is typically advised to administer it as soon as you remember and time the next dose accordingly, then resume the regular dosing schedule. However, if it's basically time for the next dose, skip the missed one, and give the next dose at the scheduled time. Do not double-dose or give extra doses.