Cytopoint (Lokivetmab)

Cytopoint is a medication used to treat allergic dermatitis and atopic dermatitis in dogs. It contains Lokivetmab, which is a monoclonal antibody and the primary active ingredient. Allergic reactions typically cause skin inflammation, known as dermatitis, which is usually triggered by environmental allergens like house dust mites and pollen. Dogs may scratch and rub their skin, leading to secondary infections caused by bacteria and yeast. The medication comes in an injectable sterile liquid solution form.

Cytopoint blocks the body’s biochemical pathway that causes itching. The key ingredient in Cytopoint, Lokivetmab, is a monoclonal antibody, which is a specific protein designed to target and bind to interleukin-31. This protein is responsible for triggering itching and dermatitis in dogs. Lokivetmab works by latching onto interleukin-31 and inhibiting its activity, decreasing itchiness and inflammation in the skin. Cytopoint treatment targets itching but other medication may be required to treat skin infections secondary to scratching.

Cytopoint is given under the skin (subcutaneously) by a veterinarian. The amount administered will depend on your dog's weight. The frequency of treatment will be determined by your veterinarian, however, it is typically given once a month.

Overdose:

Overdose is rare as it is typically stored and administered by your veterinarian. However, if you suspect your pet is experiencing adverse effects from any medication, contact your veterinarian immediately or the New Zealand National Poisons Centre (www.poisons.co.nz/animal-helpline/  or call 0800 869 738).

• Age: Not recommended for very young puppies; consult a veterinarian for age-specific guidance.
• Pregnancy and Lactation: The safety of Cytopoint in pregnant or lactating dogs has not been established.
• Allergy to Cytopoint: Dogs with a known hypersensitivity to Cytopoint or any of its components should not receive the medication.
• Infection: Dogs with active or chronic infections should be evaluated and treated by a vet, as Cytopoint may interfere with the immune response.
• Underlying Health Conditions: Dogs with certain health conditions may require careful assessment before administration.
• Concurrent Medications: The interaction of Cytopoint with other medications has not been fully explored. Inform your vet about any medications your dog is taking.

Cytopoint is generally well-tolerated and considered safe. Like all medications, it can have side effects, including:

• Injection Site Reactions: Irritation, swelling, bleeding, or pain at the site of injection.
• Vomiting and Diarrhoea: Gastrointestinal issues may occur but are usually mild and transient.
• Lethargy: Some dogs may appear tired or less active after receiving Cytopoint.
• Appetite Changes: Decreased appetite has been reported in some cases.

Although very rare, allergic reactions to Cytopoint can occur, presenting as facial swelling, hives, itching, or difficulty breathing.

Cytopoint should be stored upright and kept refrigerated (2-8°C), avoiding prolonged exposure to higher temperatures or direct sunlight.

How long will it take for Cytopoint to begin working?

• Typically, the treatment will begin to work within eight hours of the injection and remains effective for 4 to 8 weeks.

How is Cytopoint administered?

• Cytopoint is given via subcutaneous injection by a veterinarian, with dosage based on the dog’s weight.

Is Cytopoint safe to use with other medications?

• Consult your veterinarian if your pet is on any medication to ensure it is compatible with Cytopoint.

Can Cytopoint be used for cats?

• This article focuses on Cytopoint for dogs. Consult a veterinarian for treatment options suitable for cats.