Clopidogrel (Clopidogrel Besilate)

Clopidogrel is a prescription medication containing Clopidogrel Besilate as the primary active ingredient. Clopidogrel is commonly used in cats and dogs to treat or prevent blood clots. This drug is used in conditions such as immune-mediated hemolytic anaemia (IMHA) in dogs or hypertrophic cardiomyopathy and aortic thromboembolism in cats. Blood clots pose a significant health risk as they can lead to serious conditions like stroke, paralysis, or lung injury.

Clopidogrel belongs to the class of drugs known as antiplatelet medications. Platelets play a crucial role in blood clotting. In pets with a predisposition to excessive clotting, clopidogrel helps prevent these platelets from sticking together, thereby reducing the formation of dangerous clots.

Always follow your veterinarian's instructions or the directions on the medication label when administering clopidogrel. Typically, it is given once daily, with a possible higher initial dose. Since clopidogrel has a bitter taste and can upset the stomach, it's advisable to administer it with food.

Missed dose:

If you miss a dose, consult with your vet. Usually, you'll be advised to give it when remembered or skip it if it's nearly time for the next dose. Avoid giving extra or double doses.

Overdose:

Overdoses of clopidogrel are rare. However, in large overdoses, bleeding or vomiting might occur, and symptoms could persist for several days. In severe cases, a platelet transfusion may be necessary. If you suspect an overdose, contact emergency veterinary care, or reach out to the New Zealand National Poisons Centre (www.poisons.co.nz/animal-helpline/ Phone: 0800 869 738).

Clopidogrel should be avoided in pets with bleeding disorders, recent surgery or trauma. It should be used with caution when pets are being treated with other medications that can affect clotting, such as NSAIDs. It should be used with caution in pets with liver disease.

While clopidogrel is generally well-tolerated in pets, some side effects may occur, including vomiting, loss of appetite, diarrhoea, and in rare cases, anaemia in cats. Administering the medication with food can help mitigate digestive issues. If you observe any of the above side effects, contact your veterinarian immediately.

Store clopidogrel at controlled room temperatures, ensuring the container is tightly sealed to protect from moisture and light. Keep out of reach of children and pets.

Your vet might recommend specific monitoring or testing based on your pet's individual needs and other medications they are on. Contact your vet if you notice worsening of your pet's condition, suspect an overdose, or have additional queries about clopidogrel use.

Is Clopidogrel the same as aspirin?

• No. While aspirin was previously used for anti-clotting purposes, clopidogrel is now generally preferred due to fewer side effects. Studies suggest clopidogrel is safer and more effective for preventing clot formation in cats compared to aspirin.

Can clopidogrel cause side effects in pets?

• Yes, but side effects are relatively rare. They may include vomiting, loss of appetite, diarrhoea, and, in some rare cases, anaemia in cats. Administering clopidogrel with food can help reduce digestive discomfort.

What should I do in case of an overdose?

• If you suspect an overdose of clopidogrel in your pet, immediately contact your veterinarian or the New Zealand National Poisons Centre at www.poisons.co.nz/animal-helpline/ or 0800 869 738 for advice.