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Clompoze (Clomipramine Hydrochloride)

Written by Dr. Feargus McConnell, BVSc on the Jan.16, 2024

Petdirect is dedicated to providing educational pet health content for pet parents. This article was written and reviewed by veterinary professionals to answer common questions about your pet’s medication. Our focus is on delivering unbiased information to help you understand how medication works, its potential side effects, and FAQs for your reference. Always administer medication directly as prescribed by your vet. This article shouldn’t take the place of advice from your vet.

What is Clompoze?

Clompoze contains the active ingredient Clomipramine Hydrochloride and is primarily prescribed for pets with behaviour issues like separation anxiety, and obsessive-compulsive disorders. In dogs this can include problems such as separation anxiety, excessive barking, destructive behaviour, and house soiling. It's also used in cats to treat urine spraying. Clompoze is frequently prescribed for various types of pet anxiety at the discretion of the veterinarian. It is important to consult your veterinarian to determine if this medication is suitable for your pet. Clompoze should be used in conjunction with behaviour training and modifying the pet’s environment to address behaviour problems and anxiety.

How does it work?

Clomipramine is a tricyclic antidepressant (TCA) that functions by increasing serotonin and norepinephrine levels in the brain which affect mood balance.

Dose and Administration

It is important to follow your veterinarian's directions and the instructions on the drug label. It is usually recommended to administer Clompoze at the same time each day. Give with food. The dose must be tapered-off and do not abruptly stop giving the medication. The dose must be gradually reduced over a period of time as advised by your vet.

Missed dose:

If you miss a dose, consult your veterinarian for advice. Generally, you may be instructed to administer it when remembered or skip it if the next dose is due soon. It is important to avoid double dosing.

Overdose:

Symptoms of a Clomipramine overdose can be severe and include sedation, tremors, abnormal heart rhythm, seizures, and collapse. In such cases, immediately contact your veterinarian or the New Zealand National Poisons Centre (www.poisons.co.nz/animal-helpline/ phone number 0800 869 738).

Contraindications and Precautions

Not recommended for dogs or cats with cardiac arrhythmias, epilepsy or glaucoma. Use with caution in dogs and cats with a known history of urinary tract obstruction.

Clompoze is not recommended for treatment of aggression, or for treating a dog or cat that has a history of aggressive behaviour. Use with caution in cats.

Potential Side Effects

Some pets may experience side effects such as:

  • Lethargy or fatigue (temporary)
  • Vomiting
  • Diarrhoea
  • Grogginess
  • Decreased appetite
  • Constipation
  • Liver irritation
  • Urinary retention

If severe lethargy or other significant side effects are observed, contact your veterinarian immediately.

Storage

It is important to check the prescription label for specific storage requirements. Usually, Clompoze is stored at a controlled room temperature in a tightly closed container to protect from moisture and light. It is very important to keep out of reach of children and pets.

Frequently Asked Questions (FAQ)

How long does it take for Clompoze to start working in dogs and cats?  

  • For the most accurate assessment it is essential to consult with your veterinarian regarding your pet’s specific condition and needs. Usually, the effectiveness of clomipramine can typically be assessed within two months.

Can Clompoze help with dog barking?  

  • Along with behaviour modification training, Clompoze may help manage inappropriate barking in dogs. It is important to consult these concerns with your veterinarian to ensure if this treatment is suitable.

Will Clompoze affect my pet's personality or energy levels?

  • It's important to note that each pet may react differently to Clompoze. The goal of the medication is to help manage anxiety and related behaviours, not to sedate or fundamentally change the animal's personality. If you have concerns please consult your veterinarian.

Are there any types of pets that should not be prescribed Clompoze?

  • It is important to follow your veterinarian's advice, however breeding, pregnant or lactating dogs and cats are generally recommended to avoid this medication.

Conclusion

This article is intended for educational purposes and does not replace professional veterinary advice. For any concerns or questions about Clompoze or your pet's health, always consult your veterinarian.