Canaural (Frusidic, Framycetin, Nystatin, Prednisolone)

Canaural Ear Suspension is designed for treating otitis externa (outer ear infection) and skin conditions caused by bacteria and fungi in cats and dogs. It is composed of Fusidic acid, Framycetin, Nystatin and Prednisolone. Its combination of ingredients effectively targets bacteria, fungi, and ear mites, responsible for acute and chronic otitis externa in dogs and cats.

The function of the main active ingredients in Canaural are:

• Fusidic Acid: An antibiotic effective against Staphylococcus species, including Methicillin-susceptible and Methicillin-resistant Staphylococcus pseudintermedius, as well as Streptococci.
• Framycetin: A broad-spectrum antibiotic that is particularly effective against Gram-negative species like Pseudomonas and Proteus spp. It works synergistically with Fusidic acid against Staphylococcus pseudintermedius.
• Nystatin: An antifungal agent highly effective against yeasts, including Malassezia pachydermatis.
• Prednisolone: A commonly used corticosteroid that provides anti-inflammatory and antipruritic (anti-itching) effects.

Additionally, Canaural’s ingredients are suspended in a bland oil base, which helps to soften and dissolve ear wax (cerumen) and ensures penetration through the ear canal.

It is important to follow as prescribed by your veterinarian, however as a guide:

Frequency: Typically administered twice a day (morning and evening) or as prescribed.

Application Method:

• Shake the bottle before use.
• Gently restrain your pet to prevent head shaking.
• For dogs with floppy ears, fold back the ear flap.
• Apply the prescribed dose into the ear canal (often 5-10 drops).
• Gently massage the base of the ear canal.
• Wipe away any excess product.

Dosage: Follow your veterinary surgeon's advice regarding the dose.

Cleanliness: Ensure the applicator is clean to avoid cross-contamination.

Duration: Consult your veterinarian.

Not to be used when there is a perforated eardrum. Not to be used with products known to be ototoxic (damaging to the inner ear). Not to be used in animals with known hypersensitivity to the active ingredients. Not recommended in pregnant or lactating animals.

While generally well-tolerated, Canaural can cause temporary or prolonged hearing loss and older dogs are at higher risk. Allergic reactions to the product are also possible. If you notice hearing loss in your pet, stop giving Canaural and contact your veterinarian.

In particular prednisolone can have potential side effects. As an anti-inflammatory corticosteroid its dosage should be minimal for medium to long-term use. This is because it can suppress the adrenal axis, leading to potential adrenal insufficiency after treatment ends, affecting the animal's stress response. Corticosteroids may also slow wound healing and reduce resistance to or worsen existing infections.

If any of the following side effects are observed, contact your veterinarian immediately.

Store in a cool dry place out of reach of children and pets.

Can Canaural® be used for both cats and dogs?

• Yes, Canaural® is formulated for use in both cats and dogs.

How often should Canaural® be applied?

• Typically, Canaural® is applied twice a day. However, follow your veterinary specific instructions.

What should I do if I suspect an overdose or adverse reaction in my pet?

• Contact the New Zealand National Poisons Centre at www.poisons.co.nz/animal-helpline/ or phone 0800 869 738 for guidance.