Benazepril (Benazepril Hydrochloride)

Benazepril (brand names: Apex Benazepril, Acetec Benazepril) is a medication used to treat certain conditions in cats and dogs. The active ingredient is Benazepril Hydrochloride. Benazepril is an angiotensin-converting enzyme (ACE) inhibitor commonly used to manage high blood pressure (hypertension), congestive heart failure, and various types of kidney diseases in cats and dogs. While it can be administered alone, Benazepril is often used alongside other medications for treating congestive heart failure in dogs, particularly for conditions like degenerative mitral valve disease and dilated cardiomyopathy. Additionally, Benazepril is used for treating pets with kidney disease or proteinuria, a condition where proteins leak into their urine.

Benazepril functions by blocking ACE, a protein that naturally occurs in the body to constrict blood vessels. By doing so, it reduces the burden on the heart by lowering blood pressure and widening blood vessels. For pets with kidney disease, it also relaxes the kidney’s blood vessels, thereby reducing blood pressure in the kidney and minimising protein leakage into the urine.

It's crucial to follow the directions provided by your veterinarian, who will determine the appropriate dose for your pet. Typically, Benazepril is administered once daily in cats and dogs and can be given with or without food. Always consult your veterinarian before making any changes to the dosage. Ensure that your pet has access to water at all times while on this medication.

Missed a Dose:

If you miss a dose, consult your veterinarian for advice. Generally, it's advised to administer the missed dose as soon as remembered, but avoid giving extra or double doses.

Over Dose:

In case of an overdose, characterised by symptoms such as weakness, vomiting, high heart rate, collapse, or lethargy, contact your veterinarian or seek emergency veterinary care immediately. For additional help, you can contact the New Zealand National Poisons Centre at www.poisons.co.nz/animal-helpline/ or phone 0800 869 738.

Avoid administering to pets with known allergies to Benazepril or any other ACE inhibitors. Caution is also advised when using it in pets with low sodium levels, low blood pressure, heart disease, lupus, or abnormal blood cells. In pets with pre-existing conditions such as acute kidney injury or those in critical condition, benazepril should be avoided. While not typically advised in pregnant animals unless the potential benefits significantly surpass the risks, it should also be used carefully in nursing pets.

While Benazepril is generally safe and well-tolerated in pets, some common side effects may include:

• Low blood pressure (hypotension)
• Weakness
• Loss of appetite
• Fatigue (lethargy)
• Vomiting
• Diarrhoea
• Incoordination
• Changes in thirst and urination

If you observe any side effects, consult your veterinarian immediately.

Store Benazepril tablets at a controlled room temperature below 25°C, in a tightly closed container to protect from moisture and light. Keep all medications out of reach of children and pets.

Your veterinarian may recommend specific monitoring or routine testing depending on your pet’s needs and the condition being treated.

How long does Benazepril take to work in dogs and cats?

• Benazepril should start working within 1-2 hours after administration. However, it may take several days to observe noticeable changes. Your veterinarian may suggest tests to confirm if your pet is responding to the medication.

Can Benazepril be used for conditions other than heart and kidney disease in pets?

• Benazepril is primarily used for managing hypertension, congestive heart failure, and kidney diseases in pets. It’s important to use this medication only under the guidance of a veterinarian.

What should I do if I see side effects in my pet?

• Contact your veterinarian immediately if you notice any side effects.

Are there any dietary considerations while my pet is on Benazepril?

• Your veterinarian may recommend specific dietary modifications, particularly emphasising the avoidance of high-sodium foods. This recommendation aligns with the goal of maintaining optimal blood pressure levels, a critical aspect when administering medications that are designed to lower or regulate blood pressure. Additionally, a low-sodium diet contributes to better heart health and reduces fluid retention. This effectively reduces the cardiac workload and overall supports your pets heart.